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Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and lowering the next into a water molecule, with two electrons furnished by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). CYP3A4 is predicted to be the leading CYP enzyme chargeable for mediating etizolam metabolism. CYP2C18 and CYP2C

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